Tobramycin disposition in ICU patients receiving a once daily regimen: population approach and dosage simulations

Comparing dosage adjustment methods for once-daily tobramycin in paediatric and adolescent patients with cystic fibrosis.

BACKGROUND AND OBJECTIVES Several dosage adjustment methods are currently available to individualize intravenous tobramycin dosing. This study compared different methods in terms of their recommendations for dosage adjustment, their estimation of patients' pharmacokinetic parameter values and their ability to predict subsequent observed tobramycin concentrations following once-daily tobramycin ...

Once-daily dosed gentamicin is more nephrotoxic than once-daily dosed tobramycin in clinically infected patients.

1 integron showed 100% nucleotide sequence identity to the corresponding segment of a plasmid from the human clinical P. aeruginosa strain B3 isolated in Guangzhou (accession no. EU588392). Moreover, the 3 ′ conserved region of the integron (qacED1 and sul1) and the upstream region of the bla IMP-45 gene including aacA4, the 5 ′ conserved segment (intI1) of the integron and a Tn1403-like transp...

Kinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves

The present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. Peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...

once daily combination regimen for hiv infection

Glomerular and Tubular Renal Function after Repeated Once-Daily Tobramycin Courses in Cystic Fibrosis Patients

Introduction. Antibiotic treatment regimens against Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients often include aminoglycoside antibiotics that may cause chronic renal failure after repeated courses. Aminoaciduria is an early marker of acute aminoglycoside-induced renal tubular dysfunction. We hypothesized that urinary amino acid reabsorption is decreased after repeated...